Association Between Genetic Variation in the <i>SCN10A</i> Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy

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Author(s)

    • Iio Chiharuko
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Shigematsu Yuji
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Tabara Yasuharu
    • Department of Geriatric Medicine, Ehime University Graduate School of Medicine|Center for Genomic Medicine, Kyoto University Graduate School of Medicine
    • Kohara Katsuhiko
    • Department of Geriatric Medicine, Ehime University Graduate School of Medicine
    • Miki Tetsuro
    • Department of Geriatric Medicine, Ehime University Graduate School of Medicine
    • Higaki Jitsuo
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Ogimoto Akiyoshi
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine|Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
    • Nagai Takayuki
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Suzuki Jun
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Inoue Katsuji
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Nishimura Kazuhisa
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Uetani Teruyoshi
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Okayama Hideki
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine
    • Okura Takafumi
    • Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine

Abstract

Arrhythmias are associated with reduced quality of life and poor prognosis in patients with hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the <i>SCN10A</i> gene was associated with the PR interval. We examined whether the PR prolonging allele (A allele) in the <i>SCN10A</i> gene may be associated with cardiac conduction abnormalities in HCM patients.<br>We genotyped the polymorphism in 149 HCM patients. Conduction abnormalities were defined as first-degree heart block, bundle-branch block, and bifascicular heart block. Patients were divided into two groups: group A consisted of 122 patients (82%) without a conduction abnormality; and group B consisted of 27 patients (18%) with one or more cardiac conduction abnormalities. The frequency distribution of the <i>SCN10A</i> genotypes (G/G, G/A, and A/A) among the patients with HCM was 71%, 26%, and 3%, respectively. A cardiac conduction abnormality was documented in 9% with G/G and 40% with G/A or A/A. There was a significant difference in the genotype distribution between the two groups (<i>P</i> = 0.0002). In the dominant A allele model, there was a significant difference in genotypes between the two groups (<i>P</i> < 0.0001). In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], <i>P</i> = 0.0005).<br>The rs6795970 in the <i>SCN10A</i> gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.

Journal

  • International Heart Journal

    International Heart Journal 56(4), 421-427, 2015

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130005087577
  • Text Lang
    ENG
  • ISSN
    1349-2365
  • Data Source
    J-STAGE 
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