Characteristics of Duplex Microcapsules Prepared from an Alginate-Derivative Polymer via Horseradish Peroxidase- and Catalase-Catalyzed Reactions

Access this Article

Search this Article

Author(s)

Abstract

In this study, we investigate the impact of polymer concentrations on the characteristics of duplex microcapsules prepared from an alginate derivative possessing phenolic hydroxyl moieties (Alg-Ph) via horseradish peroxidase- and catalase-catalyzed reactions. Membrane thicknesses increased from 17 to 40 µm with increasing Alg-Ph concentrations from 0.5 to 2.5% (w/v). In addition, the mechanical strength of microcapsules also increased with increasing Alg-Ph concentrations. Shrinking of microcapsules was observed in Dulbecco’s modified Eagle’s medium and simulated body fluid containing Ca<sup>2+</sup> (13.1–29.2% reduction in diameter for a 12 d incubation). The diffusivities of dextran (4, 40 or 70 kDa) through a membrane of 2.5% (w/v) Alg-Ph microcapsules were almost the same as those of a 1.5% (w/v) calcium-alginate hydrogel. The results demonstrate that it is possible to tune the characteristics of microcapsule membranes obtained through co-enzymatic reactions to customize the particular applications.

Journal

  • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 48(7), 588-591, 2015

    The Society of Chemical Engineers, Japan

Codes

  • NII Article ID (NAID)
    130005088131
  • NII NACSIS-CAT ID (NCID)
    AA00709658
  • Text Lang
    ENG
  • ISSN
    0021-9592
  • NDL Article ID
    026603318
  • NDL Call No.
    Z53-R395
  • Data Source
    NDL  J-STAGE 
Page Top