多糖類縁体の合成·機能化に基づく高性能光腫瘍造影剤の開発

• 三木 康嗣

  京都大学大学院工学研究科

書誌事項

タイトル別名

• Synthesis and Functionalization of Polysaccharide Analogues and Their Application to High-Contrast Tumor Imaging
• 多糖類縁体の合成・機能化に基づく高性能光腫瘍造影剤の開発
• タトウルイエンタイ ノ ゴウセイ ・ キノウカ ニ モトズク コウセイノウ ヒカリ シュヨウゾウエイザイ ノ カイハツ

抄録

Polymeric self-assemblies and their related aggregates have received great attention because of their huge potential to be used as tumor imaging agents. Amphiphilic polymers consisting of hydrophobic, hydrophilic, and dye segments have been widely accepted as appropriate components of polymeric self-assemblies for tumor imaging, because nanometer-size particles can be accumulated in tumor tissues by the enhanced permeability and retention effect. However, there still exists a problem with selective accumulation of the imaging probe in the target tissue. Recently, we found out the facile synthesis of biocompatible polysaccharide analogues through ring-opening metathesis polymerization of norbornadienes or 7-oxanorbornenes and dihydroxylation, and investigated the functionalization of polysaccharide analogues to be applied as high-performance contrast agents. In this account, polymeric self-assemblies consisting of highly functionalized polysaccharide analogues as contrast agents for optical and photoacoustic tumor imaging are summarized.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 73 (6), 580-594, 2015

  公益社団法人 有機合成化学協会

キーワード

• metathesis polymerization
• polysaccharide analogue
• self-assembly
• near-infrared dye
• tumor
• optical imaging
• photoacoustic imaging

詳細情報

• CRID: 1390282680318190848
• NII論文ID: 130005088784
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.73.580
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 026544769
• Web Site: http://id.ndl.go.jp/bib/026544769
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026544769
• 本文言語コード: ja
• データソース種別:
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