Effects of static interventions on disuse atrophy of the rat soleus muscle at different sites along its longitudinal axis

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Author(s)

    • Miyachi Ryo
    • Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Japan| Department of Rehabilitation, Ishikawaken Saisekai Kanazawa Hospital, Japan
    • Yamazaki Toshiaki
    • Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University: Kanazawa, Japan

Abstract

[Purpose] The purpose of our study was to verify the inhibitory effects of static intervention (heat load and muscle stretching) on disuse-related adaptation changes in the soleus muscle and to compare these effects across different sites along its longitudinal axis. [Subjects] Forty 8-week-old male Wistar rats. [Methods] The effects of heat load and/or muscle stretching in the rat soleus during hindlimb suspension were evaluated by measuring the cross-sectional area of the muscle fibers, succinate dehydrogenase activity, and number of capillaries in the proximal, middle, and distal regions. [Results] With no intervention the proximal region showed the highest reduction in the cross-sectional area, whereas the distal region showed the highest reduction in succinate dehydrogenase activity and the number of capillaries due to hindlimb suspension. These differences between the proximal and distal regions decreased with both interventions, and the effects were most pronounced with a combination of heat load and muscle stretching. [Conclusion] Differences in the muscle structure between the proximal and distal regions increased due to hindlimb suspension, and this heterogeneity associated with muscle disuse was inhibited by static intervention including heat load and muscle stretching. Furthermore, the combination of heat load and muscle stretching most reduced the heterogeneity.

Journal

  • Journal of Physical Therapy Science

    Journal of Physical Therapy Science 27(7), 2317-2321, 2015

    The Society of Physical Therapy Science

Codes

  • NII Article ID (NAID)
    130005089016
  • Text Lang
    ENG
  • ISSN
    0915-5287
  • Data Source
    J-STAGE 
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