Littermate Influence on Infant Growth in Mice: Comparison of SJL/J and ICR as          Cotransferred Carrier Embryos

KANEKO Ryosuke, KAKINUMA Toshie, SATO Sachiko, JINNO-OUE Atsushi, HATA Hidekazu

doi:10.1538/expanim.14-0009

In mice, a minimum number of healthy embryos is required to trigger and maintain pregnancy. Therefore, when recovering mouse embryos from a limited litter, one useful technique is to transfer carrier ICR embryos along with the embryos of interest, a technique referred to as cotransfer. In this study, we examined suitable mouse strains for cotransfer with C57BL/6J (B6) embryos in regards to the maintenance of pregnancy, number of pups born, intrauterine growth, and postnatal growth. Because the coat color of B6 is black, we compared two white coat-colored strains, SJL/J and ICR. Cotransfer of SJL/J and ICR embryos had similar effects on maintenance of pregnancy, number of pups born, and intrauterine growth. However, the postnatal growth of B6 mouse pups cotransferred and grown with SJL/J pups was better than for B6 mouse pups cotransferred and grown with ICR pups, suggesting competition among littermates. These results demonstrate that cotransfer of SJL/J embryos will be useful not only as carrier embryos with B6-background embryos but also as a model system to examine littermate competition.

Littermate Influence on Infant Growth in Mice: Comparison of SJL/J and ICR as Cotransferred Carrier Embryos

この論文をさがす

抄録

収録刊行物

被引用文献 (3)*注記

参考文献 (21)*注記

関連プロジェクト

キーワード

詳細情報詳細情報について

書き出し

問題の指摘