Detection of monoclonal integration of bovine leukemia virus proviral DNA as a malignant marker in two enzootic bovine leukosis cases with difficult clinical diagnosis
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- MIURA Saori
- Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
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- HORIUCHI Noriyuki
- Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
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- MATSUMOTO Kotaro
- Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
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- KOBAYASHI Yoshiyasu
- Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
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- KAWAZU Shin-ichiro
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080–8555, Japan
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- INOKUMA Hisashi
- Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
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Abstract
Monoclonal integration of bovine leukemia virus (BLV) proviral DNA into bovine genomes was detected in peripheral blood from two clinical cases of enzootic bovine leukosis (EBL) without enlargement of superficial lymph nodes. A BLV-specific probe hybridized with 1 to 3 EcoRI and HindIII fragments in these 2 atypical EBL cattle by Southern blotting and hybridization, as well as in 3 typical EBL cattle. The probe also hybridized to a large number of EcoRI and HindIII fragments in 5 cattle with persistent leukosis. These results suggest that the detection of monoclonal integration of BLV provirus into the host genome may serve as a marker of monoclonal proliferation and malignancy in difficult to diagnose EBL cattle.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 77 (7), 883-887, 2015
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681405290112
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- NII Article ID
- 130005089949
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 026635734
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- PubMed
- 25766769
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed