アクチン線維は張力を感じ,コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである  [in Japanese] The Actin Filament as a Mechanosensor  [in Japanese]

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Author(s)

    • 辰巳 仁史 TATSUMI Hitoshi
    • 名古屋大学院医学系研究科|現 金沢工業大学バイオ・化学部 Department of Physiology, Nagoya University Graduate School of Medicine|Present Address: College of Bioscience and Chemistry, Kanazawa Institute of Technology (KIT)
    • 曽我部 正博 SOKABE Masahiro
    • 名古屋大学院医学系研究科|名古屋大学院医学系研究科 Department of Physiology, Nagoya University Graduate School of Medicine|Mechanobiology Laboratory, Nagoya University Graduate School of Medicine

Abstract

Intracellular and extracellular mechanical forces affect the dynamics of actin cytoskeletons, however, the underlying biophysical mechanisms how forces are transduced into changes in the actin dynamics remain largely unknown. We find that activity of the actin severing protein ADF/cofilin negatively depends on tension in the actin filament through tension-dependent binding/unbinding of cofilin to/from the actin filament, thereby relaxed actin filaments are severed whereas tensed ones are not. Here we review the latest knowledge on this phenomenon and discuss its biological impact.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 55(4), 187-191, 2015

    The Biophysical Society of Japan General Incorporated Association

Codes

  • NII Article ID (NAID)
    130005090035
  • NII NACSIS-CAT ID (NCID)
    AN00129693
  • Text Lang
    JPN
  • ISSN
    0582-4052
  • NDL Article ID
    026694487
  • NDL Call No.
    Z18-49
  • Data Source
    NDL  J-STAGE 
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