アクチン線維は張力を感じ，コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである [in Japanese] The Actin Filament as a Mechanosensor [in Japanese]
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Intracellular and extracellular mechanical forces affect the dynamics of actin cytoskeletons, however, the underlying biophysical mechanisms how forces are transduced into changes in the actin dynamics remain largely unknown. We find that activity of the actin severing protein ADF/cofilin negatively depends on tension in the actin filament through tension-dependent binding/unbinding of cofilin to/from the actin filament, thereby relaxed actin filaments are severed whereas tensed ones are not. Here we review the latest knowledge on this phenomenon and discuss its biological impact.
- Seibutsu Butsuri
Seibutsu Butsuri 55(4), 187-191, 2015
The Biophysical Society of Japan General Incorporated Association