膵臓<i>β</i>細胞内インスリン顆粒動態シミュレーション・モデル

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タイトル別名
  • Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell
  • 膵臓β細胞内インスリン顆粒動態シミュレーション・モデル
  • スイゾウvサイボウ ナイ インスリン カリュウ ドウタイ シミュレーション ・ モデル

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抄録

Insulin secretion from pancreatic β cells plays the central role in maintaining glucose homeostasis. Impaired insulin secretion mainly contributes to the pathogenesis and pathophysiology of type 2 diabetes mellitus. Diabetes of the type-2, which are typical among Asian patients, are caused by insufficient insulin secretions by unknown factors. For revealing the factors and dealing with them properly, it is necessary to clarify the insulin secretion mechanism in pancreatic β cells. In insulin granule kinetics, i.e. the transportation process of insulin granules produced in pancreatic β cells to the cell membrane for secretion, the granules are supposed to move along the cytoskeleton. For constructing the simulation model, we divided the model into four stages based on the skeleton of a pancreatic β cell and the principle of granule kinetics, i.e., the granule producing site, the inner layer, the outer layer and the granule secretory part. The phenomena to be reproduced are the typical secretion patterns found in healthy person, diabetic patients and healthy person with incretins. In this paper, a series of simulations based on the data concerning insulin granules kinetics have been carried out, where the typical secretion patterns have been reproduced by setting the parameters adequately according to the observation in a pancreatic β cell without changing the model itself. Through these simulation results, the potential of the proposed model has been confirmed.

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