膵臓<i>β</i>細胞内インスリン顆粒動態シミュレーション・モデル Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell

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Insulin secretion from pancreatic <i>β</i> cells plays the central role in maintaining glucose homeostasis. Impaired insulin secretion mainly contributes to the pathogenesis and pathophysiology of type 2 diabetes mellitus. Diabetes of the type-2, which are typical among Asian patients, are caused by insufficient insulin secretions by unknown factors. For revealing the factors and dealing with them properly, it is necessary to clarify the insulin secretion mechanism in pancreatic <i>β</i> cells. In insulin granule kinetics, i.e. the transportation process of insulin granules produced in pancreatic <i>β</i> cells to the cell membrane for secretion, the granules are supposed to move along the cytoskeleton. For constructing the simulation model, we divided the model into four stages based on the skeleton of a pancreatic <i>β</i> cell and the principle of granule kinetics, i.e., the granule producing site, the inner layer, the outer layer and the granule secretory part. The phenomena to be reproduced are the typical secretion patterns found in healthy person, diabetic patients and healthy person with incretins. In this paper, a series of simulations based on the data concerning insulin granules kinetics have been carried out, where the typical secretion patterns have been reproduced by setting the parameters adequately according to the observation in a pancreatic <i>β</i> cell without changing the model itself. Through these simulation results, the potential of the proposed model has been confirmed.

収録刊行物

  • 電気学会論文誌. C

    電気学会論文誌. C 135(8), 963-970, 2015

    一般社団法人 電気学会

各種コード

  • NII論文ID(NAID)
    130005090618
  • NII書誌ID(NCID)
    AN10065950
  • 本文言語コード
    JPN
  • ISSN
    0385-4221
  • NDL 記事登録ID
    026676940
  • NDL 請求記号
    Z16-795
  • データ提供元
    NDL  J-STAGE 
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