Lupus Anticoagulant-hypoprothrombinemia Syndrome Complicated with Hashimoto's Thyroiditis and Adult T-cell Leukemia/Lymphoma, Smoldering Type

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  • Shimabukuro Natsuki
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus Center of Bone Marrow Transplantation, Ryukyu University Hospital
  • Nishi Yukiko
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Nakachi Sawako
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus Center of Bone Marrow Transplantation, Ryukyu University Hospital
  • Tamaki Keita
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Tedokon Iori
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Morichika Kazuho
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Tomoyose Takeaki
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Fukushima Takuya
    Laboratory of Hematoimmunology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus
  • Masuzaki Hiroaki
    Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus

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Other Title
  • 橋本病と成人T細胞白血病リンパ腫（くすぶり型）を合併したループスアンチコアグラント低プロトロンビン血症症候群の1例
  • 今月の症例 橋本病と成人T細胞白血病リンパ腫(くすぶり型)を合併したループスアンチコアグラント低プロトロンビン血症症候群の1例
  • コンゲツ ノ ショウレイ ハシモトビョウ ト セイジン Tサイボウ ハッケツビョウ リンパシュ(クスブリ ガタ)オ ガッペイ シタ ループスアンチコアグラント テイプロトロンビン ケツショウ ショウコウグン ノ 1レイ

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Abstract

ループスアンチコアグラント低プロトロンビン血症症候群（lupus anticoagulant-hypoprothrombinemia syndrome：LA-HPS）はLAにプロトロンビン欠乏を合併した疾患であり，血栓症だけでなく，重篤な出血を来たすことがある．症例は74歳女性．大球性貧血の精査目的に入院し，凝固検査にてAPTT延長を認めた．複数の凝固因子活性の低下とLA陽性からLA-HPSと診断した．同時に，橋本病，成人T細胞白血病リンパ腫（adult T-cell leukemia/lymphoma：ATL）（くすぶり型）も合併していることが判明した．

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