NMR Detection and Characterization of I-quartets in Parallel DNA Quadruplexes

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Author(s)

Abstract

Four inosine bases (Is) can be cyclically and planarly associated through four hydrogen bonds to form a macrocycle called an I-quartet, in a manner similar to that of the well-known guanine (G)-one. We identified and characterized I-quartets formed in parallel DNA quadruplexes using <sup>1</sup>H NMR. Comparative studies on I- and G-quartets formed in parallel DNA quadruplexes revealed remarkable differences in their physicochemical properties that could be interpreted in terms of buckling of the quartet plane.

Journal

  • Chemistry Letters

    Chemistry Letters 44(8), 1107-1109, 2015

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130005092593
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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