NMR Detection and Characterization of I-quartets in Parallel DNA Quadruplexes
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Four inosine bases (Is) can be cyclically and planarly associated through four hydrogen bonds to form a macrocycle called an I-quartet, in a manner similar to that of the well-known guanine (G)-one. We identified and characterized I-quartets formed in parallel DNA quadruplexes using <sup>1</sup>H NMR. Comparative studies on I- and G-quartets formed in parallel DNA quadruplexes revealed remarkable differences in their physicochemical properties that could be interpreted in terms of buckling of the quartet plane.
- Chemistry Letters
Chemistry Letters 44(8), 1107-1109, 2015
The Chemical Society of Japan