Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects
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- Tsuboi Atsuko
- Grand Tower Medical Court, Japan Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
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- Ito Chikako
- Grand Tower Medical Court, Japan
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- Fujikawa Rumi
- Grand Tower Medical Court, Japan
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- Yamamoto Hideya
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
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- Kihara Yasuki
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biochemical and Health Sciences, Japan
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Abstract
Objective Although a relationship between post-challenge hyperglycemia and arterial stiffness has been reported, the relationship between the postprandial glucose levels and cardio-ankle vascular index (CAVI) in non-diabetic subjects is not clear. This study thus evaluated the association between the postprandial glucose levels after a composite meal and the degree of arterial stiffness measured according to CAVI in non-diabetic subjects.<br> Methods The subjects included 1,291 individuals (655 men and 636 women; mean age, 48.6 years; range, 23-85 years) who underwent medical examinations, including blood tests and CAVI assessments, between October 2005 and April 2012. The 1-hour postprandial glucose levels were determined after a 600-kcal traditional Japanese meal.<br> Results The CAVI values were significantly higher in the subjects with higher 1-hour postprandial glucose levels (≥140 mg/dL in men; ≥158 mg/dL in women). A simple regression analysis indicated that the CAVI values were significantly correlated with the 1-hour postprandial glucose levels in men (r=0.286, p<0.0001) and women (r=0.228, p<0.0001). After adjusting for age, BMI, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, 1-hour postprandial glucose, homeostatis model assessment of insulin resistance, estimated glemerular filtration rate, and high sensitive C-reactive protein, stepwise multiple regression analysis demonstrated that the 1-hour postprandial glucose level was an independent predictor associated with the CAVI in men (p=0.003) and older women 50 years of age or older (p=0.003).<br> Conclusion This study demonstrated that the 1-hour postprandial glucose levels are associated with increased CAVI values in non-diabetic men and older women 50 years of age or older.<br>
Journal
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- Internal Medicine
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Internal Medicine 54 (16), 1961-1969, 2015
The Japanese Society of Internal Medicine
