<sup>18</sup>F-AV45（Florbetapir F 18）を用いた認知症における脳アミロイドイメージング [in Japanese] Amyloid imaging of dementia using the radioligand <sup>18</sup>F-AV-45 (Florbetapir F 18) [in Japanese]
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要旨 【目的】<sup>18</sup>F-AV45（Florbetapir）をアルツハイマー病（AD），軽度認知機能障害（MCI），前頭側頭葉型認知症（FTLD），正常対照（HC）に対し用い比較検討し，その有用性を検討する．【方法】対象は，AD 28 例，MCI 14例，FTLD 11 例，HC 8 例．<sup>18</sup>F-AV45 を約370 MBq 静脈投与し，小脳に対する脳各部位のstandardized uptake value ratio（SUVR）を指標とした．症例群間でSUVR 値を比較した．AD とMCI におけるSUVR 値と認知機能検査との関連を検討した．【結果】SUVR 値は，AD は高値，MCI は中間値，HC とFTLD は低値であった．ADとMCI におけるSUVR 値と認知機能検査との相関はなかった．【結論】<sup>18</sup>F-AV45 アミロイドイメージングは，認知症性疾患の鑑別に有用であり，簡便で多数の組入れが可能な検査として期待される．
Purpose: To quantitatively evaluate fibrillar β-amyloid burden in patients with probable Alzheimer's disease (AD), mild cognitive impairment (MCI), and frontotemporal lobar degeneration (FTLD), as well as in healthy control (HC), using 18F-AV-45 (florbetapir) positron emission tomography (PET). Methods: We performed <sup>18</sup>F-AV-45 PET on 28 patients with probable AD (16 men; mean Mini-Mental State Examination (MMSE) score, 22±5.0; mean age, 69.8±10.4 years), 14 patients with MCI (7 men; mean MMSE score, 26±3.4; mean age, 67.1±6.1 years), 11 patients with FTLD (8 men; mean MMSE score, 25.6±2.5; mean age, 65.5±11.8 years), and 8 HCs (3 men; mean age, 70.8±6.1 years). Dynamic PET was performed from 0 to 80 min after tracer injection (370 MBq), and time-activity curves were constructed. Standardized uptake value (SUV) and cortex-to-cerebellum SUV ratio (SUVR) were calculated for cortical (frontal, temporal, parietal, and occipital lobes) and non-cortical (hippocampus, caudate, putamen, thalamus, and pons) regions of interest. We made an examination of MMSE and WMS-R for all patients and HC. Results: In the 10-min period from 50 to 60 min after tracer injection, cortex-to-cerebellum SUVR were 1.39–1.52 for patients with AD, 1.27–1.34 for patients with MCI, 1.02–1.18 for patients with FTLD, and 1.12–1.33 for HC. In HC, SUVR was higher for white matter than for gray matter. However, for patients with AD, SUVR was higher for gray matter than for white matter. In the frontal, parietal, and temporal regions, SUVR was greater in patients with AD than in patients with FTLD or HC. In the frontal and parietal regions, SUVR was greater in patients with MCI than in FTLD. No significant difference was evident between SUVR in patients with AD and in patients with MCI. In the occipital regions, SUVR was similar in patients with all diseases and in HC. No significant difference was observed in the cortical retention of amyloid of all cortical regions for all subjects. Among patients with AD and MCI, the SUVR of all cortical regions was similar in apolipoprotein E ε4 (APOE-ε4) carriers and ε4 non-carriers. Among patients with AD and MCI, no significant correlation was observed between SUVR and scores of MMSE and WMS Delayed Recall. Conclusion: These results suggest that <sup>18</sup>F-AV-45 PET may be valuable for discriminating between AD dementia and non-AD dementia.
- Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 26(2), 11-18, 2015
The Japanese Society of Cerebral Blood Flow and Metabolism