Amyloid imaging of dementia using the radioligand ¹⁸F-AV-45 (Florbetapir F 18)

• Shibata Toshihide

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Yonezawa Hisashi

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Takahashi Junko

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Kudo Masako

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Obara Satoko

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Suzuki Masako

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Ishizuka Naoki

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Fujisawa Yutaka

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

• Sasaki Toshiaki

  Cyclotron Reseach Center, Iwate Medical University

• Terasaki Kazunori

  Cyclotron Reseach Center, Iwate Medical University

• Sera Kohichiro

  Cyclotron Reseach Center, Iwate Medical University

• Terayama Yasuo

  Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University

Bibliographic Information

Other Title

• ¹⁸F-AV45（Florbetapir F 18）を用いた認知症における脳アミロイドイメージング

Abstract

Purpose: To quantitatively evaluate fibrillar β-amyloid burden in patients with probable Alzheimer’s disease (AD), mild cognitive impairment (MCI), and frontotemporal lobar degeneration (FTLD), as well as in healthy control (HC), using 18F-AV-45 (florbetapir) positron emission tomography (PET). Methods: We performed ¹⁸F-AV-45 PET on 28 patients with probable AD (16 men; mean Mini-Mental State Examination (MMSE) score, 22±5.0; mean age, 69.8±10.4 years), 14 patients with MCI (7 men; mean MMSE score, 26±3.4; mean age, 67.1±6.1 years), 11 patients with FTLD (8 men; mean MMSE score, 25.6±2.5; mean age, 65.5±11.8 years), and 8 HCs (3 men; mean age, 70.8±6.1 years). Dynamic PET was performed from 0 to 80 min after tracer injection (370 MBq), and time-activity curves were constructed. Standardized uptake value (SUV) and cortex-to-cerebellum SUV ratio (SUVR) were calculated for cortical (frontal, temporal, parietal, and occipital lobes) and non-cortical (hippocampus, caudate, putamen, thalamus, and pons) regions of interest. We made an examination of MMSE and WMS-R for all patients and HC. Results: In the 10-min period from 50 to 60 min after tracer injection, cortex-to-cerebellum SUVR were 1.39–1.52 for patients with AD, 1.27–1.34 for patients with MCI, 1.02–1.18 for patients with FTLD, and 1.12–1.33 for HC. In HC, SUVR was higher for white matter than for gray matter. However, for patients with AD, SUVR was higher for gray matter than for white matter. In the frontal, parietal, and temporal regions, SUVR was greater in patients with AD than in patients with FTLD or HC. In the frontal and parietal regions, SUVR was greater in patients with MCI than in FTLD. No significant difference was evident between SUVR in patients with AD and in patients with MCI. In the occipital regions, SUVR was similar in patients with all diseases and in HC. No significant difference was observed in the cortical retention of amyloid of all cortical regions for all subjects. Among patients with AD and MCI, the SUVR of all cortical regions was similar in apolipoprotein E ε4 (APOE-ε4) carriers and ε4 non-carriers. Among patients with AD and MCI, no significant correlation was observed between SUVR and scores of MMSE and WMS Delayed Recall. Conclusion: These results suggest that ¹⁸F-AV-45 PET may be valuable for discriminating between AD dementia and non-AD dementia.

Journal

• Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)

  Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 26 (2), 11-18, 2015

  The Japanese Society of Cerebral Blood Flow and Metabolism

Keywords

• ¹⁸F-AV45 (Florbetapir F 18)
• positron-emission-tomography (PET)
• brain amyloid imaging
• dementia

Details

• CRID: 1390001205757666048
• NII Article ID: 130005093691
• DOI: 10.16977/cbfm.26.2_11
• ISSN: 21887519
• ISSN: 09159401
• Web Site: https://www.jstage.jst.go.jp/article/cbfm/26/2/26_11/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016292566
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed