一次運動野刺激による中枢性脳卒中後疼痛患者の機能的結合  [in Japanese] Functional connectivity of the primary motor cortex stimulation in patients with central post-stroke pain  [in Japanese]

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Author(s)

    • 細見 晃一 Hosomi Koichi
    • 大阪大学大学院医学系研究科 脳神経機能再生学|大阪大学大学院医学系研究科 脳神経外科学 Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University|Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 齋藤 洋一 Saitoh Youichi
    • 大阪大学大学院医学系研究科 脳神経機能再生学|大阪大学大学院医学系研究科 脳神経外科学 Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University|Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 清水 豪士 Shimizu Takeshi
    • 大阪大学大学院医学系研究科 脳神経機能再生学|大阪大学大学院医学系研究科 脳神経外科学 Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University|Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 圓尾 知之 Maruo Tomoyuki
    • 大阪大学大学院医学系研究科 脳神経機能再生学|大阪大学大学院医学系研究科 脳神経外科学 Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University|Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • Ming Koo Hui Ming Koo Hui
    • 大阪大学大学院医学系研究科 脳神経外科学 Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 谷 直樹 Tani Naoki
    • 大阪大学大学院医学系研究科 脳神経外科学 Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 後藤 雄子 Goto Yuko
    • 大阪大学大学院医学系研究科 脳神経機能再生学|大阪大学大学院医学系研究科 脳神経外科学 Department of Neuromodulation and Neurosurgery, Graduate School of Medicine, Osaka University|Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 貴島 晴彦 Kishima Haruhiko
    • 大阪大学大学院医学系研究科 脳神経外科学 Department of Neurosurgery, Graduate School of Medicine, Osaka University
    • 吉峰 俊樹 Yoshimine Toshiki
    • 大阪大学大学院医学系研究科 脳神経外科学 Department of Neurosurgery, Graduate School of Medicine, Osaka University

Abstract

   We have previously reported the efficacy of 5 Hz repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) in relief of central post–stroke pain (CPSP). The objective of this study was to explore changes of functional connectivity related to CPSP condition, and to assess changes of functional connectivity induced by rTMS in patients with CPSP. In 14 patients with CPSP and 14 control subjects, resting–state functional MRI were taken. Twelve of these patients received 5 Hz–rTMS of M1, and underwent resting–state functional MRI before and after rTMS. Functional connectivity associated with motor and default mode networks increased in patients with CPSP compared with control subjects. Moreover, functional connectivity associated with default mode network and anterior cingulate cortex decreased after rTMS. These findings suggest that several functional networks are involved in pathophysiology of CPSP and mechanisms of action of rTMS.

Journal

  • PAIN RESEARCH

    PAIN RESEARCH 30(3), 173-176, 2015

    JAPANESE ASSOCIATION FOR STUDY OF PAIN

Codes

  • NII Article ID (NAID)
    130005093936
  • Text Lang
    JPN
  • ISSN
    0915-8588
  • Data Source
    J-STAGE 
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