Effects of Phosphoryl Oligosaccharides of Calcium (POs-Ca) on Epidermal Cells and Human Skin
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- Sambe Haruyo
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Sugimoto Kazuhisa
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Nomura Koji
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Kuriki Takashi
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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抄録
Phosphoryl oligosaccharides of calcium (POs-Ca) is a calcium salt of phosphoryl maltooligosaccharides made from potato starch. POs-Ca has high solubility in water and it can supply both calcium ion and acidic oligosaccharides in an aqueous medium. In this study, we evaluated effects of POs-Ca on cultured normal human epidermal keratinocytes (NHEK) and human skin. Several in vitro studies using cultured NHEK demonstrated that POs-Ca promoted NHEK differentiation, tight junction formation, intercellular lipid production, and gene expression involved in stratum corneum condition, skin barrier function and hydration. Skin penetration study using a three-dimensional epidermal model demonstrated that POs-Ca was able to provide both calcium ion and phosphoryl oligosaccharides to the epidermis. Furthermore, an in vivo study demonstrated that POs-Ca improved human skin conditions including hydration, barrier function, stratum corneum condition, and skin texture. These results suggest that POs-Ca can be a superior active agent for healthy epidermis.
収録刊行物
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- Journal of Applied Glycoscience
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Journal of Applied Glycoscience 62 (3), 107-113, 2015
日本応用糖質科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206291696640
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- NII論文ID
- 130005094610
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- NII書誌ID
- AA11809133
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- ISSN
- 18807291
- 13447882
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- NDL書誌ID
- 026695808
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可