Clinicopathological features of Riedel’s thyroiditis associated with IgG4-related disease in Japan
-
- Takeshima Ken
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Inaba Hidefumi
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Ariyasu Hiroyuki
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Furukawa Yasushi
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Doi Asako
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Nishi Masahiro
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
-
- Hirokawa Mitsuyoshi
- Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe 650-0011, Japan
-
- Yoshida Akira
- Department of Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan
-
- Imai Ryoukichi
- Department of Otorhinolaryngology, KKR Sapporo Medical Center, Sapporo 062-0931, Japan
-
- Akamizu Takashi
- The 1<sup>st</sup> Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
Bibliographic Information
- Other Title
-
- Clinicopathological features of Riedel’s thyroiditis associated with IgG4-related disease in Japan
Search this article
Abstract
Riedel’s thyroiditis (RT) is a rare chronic fibrosing disorder characterized by a hard, infiltrative lesion in the thyroid gland, which is often associated with multifocal fibrosclerosis. Immunoglobulin G4-related disease (IgG4-RD) is typified by infiltration of IgG4-positive plasma cells into multiple organs, resulting in tissue fibrosis and organ dysfunction. In order to evaluate the clinicopathological features of RT and its relationship with IgG4-RD, we performed a Japanese literature search using the keywords “Riedel” and “Riedel’s thyroiditis.” We used the electronic databases Medline and Igaku Chuo Zasshi, the latter of which is the largest medical literature database in Japan. The diagnosis of RT was based on the presence of a fibroinflammatory process with extension into surrounding tissues. Only 10 patients in Japan fulfilled RT diagnostic criteria during the 25-year period between 1988 and 2012. Two patients with confirmed IgG4/IgG immunohistochemical findings demonstrated 43 and 13 IgG4-positive plasma cells per high-power field, respectively, and the IgG4-positive/IgG-positive plasma cell ratios of 20% and less than 5%. Of the 10 patients with RT, two received glucocorticoids, one of whom experienced marked shrinkage of the thyroid lesion. One patient had extra-thyroid involvement in the form of retroperitoneal fibrosis. Although the clinicopathological features of RT suggest that IgG4-RD may be the underlying condition in some cases, further investigation is needed to clarify the etiology of RT in relation to IgG4-RD.
Journal
-
- Endocrine Journal
-
Endocrine Journal 62 (8), 725-731, 2015
The Japan Endocrine Society
