Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan

• Mori Kenta

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Ishida Tatsuro

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Yasuda Tomoyuki

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Hasokawa Minoru

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Monguchi Tomoko

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Sasaki Maki

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Kondo Kensuke

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Nakajima Hideto

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Shinohara Masakazu

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Shinke Toshiro

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Irino Yasuhiro

  Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine

• Toh Ryuji

  Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine

• Nishimura Kunihiro

  Department of Preventive Medicine and Epidemiologic Informatics, Office of Evidence-Based Medicine and Risk Analysis, National Cerebral and Cardiovascular Center

• Hirata Ken-ichi

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

抄録

Background:Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.Methods and Results:A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.Conclusions:Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan. (Circ J 2015; 79: 2017–2025)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (9), 2017-2025, 2015

  一般社団法人 日本循環器学会

キーワード

• Coronary artery disease
• Elaidic acid
• Hyperlipidemia
• Metabolic syndrome
• Trans-fatty acid

詳細情報

• CRID: 1390282680084536576
• NII論文ID: 130005095322
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-14-0750
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026690537
• PubMed: 26166015
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026690537
• Web Site: https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-14-0750/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016111226
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
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  • KAKEN
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