書誌事項
- タイトル別名
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- Crystal Structure of Hemagglutinin from Type B <i>Clostridium Botulinum</i>
- ボツリヌスキン ユライ ヘマグルチニン ノ リッタイ コウゾウ
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Botulinum neurotoxins (BoNTs), which are produced by Clostridium botulinum, are the most potent toxins, and cause the highly lethal food poisoning. BoNTs are produced as the assemblies with non-toxic components. Hemagglutinin (HA), one of the non-toxic components, has three biological activities: one is protecting BoNT from degradation in gastrointestinal tract, another is binding activity to carbohydrates and the other is disrupting of the epithelial barrier by direct binding to E-cadherin, which are critical for oral toxicity of BoNT. Here, we review the study on the crystal structure of type B whole HA. This structure reveals whole HA to be a huge triskelion-shaped molecule composed of 12 subcomponents, and biochemical data show that these functions of HA are employed at distinct sites.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 57 (4), 233-238, 2015
日本結晶学会
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キーワード
詳細情報
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- CRID
- 1390001204089267200
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- NII論文ID
- 130005096000
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 026728703
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可