(−)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones

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  • Song Won-Young
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • Aihara Yoshiko
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • Hashimoto Takashi
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • Kanazawa Kazuki
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • Mizuno Masashi
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

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Abstract

The anorexigenic gut hormones, cholecystokinin (CCK), glucagon-like peptide (GLP)-1 and peptide tyrosine-tyrosine (PYY), are released in response to food intake from the intestines. Dietary nutrients have been shown to stimulate these hormones. Some non-nutrients such as polyphenols show anorexigenic effects on humans. In the present study, we examined whether dietary polyphenols can stimulate secretion of these gut hormones. Caco-2 cells expressed mRNA of the gut hormones, CCK, PC1 (prohormone convertase 1), GCG (glucagon) and PYY. CCK, GLP-1 and PYY were secreted from Caco-2 cells after adding sugars, amino acids or fatty acids. Using Caco-2 cells, epigallocatechin-3-gallate (EGCG), chlorogenic acid and ferulic acid induced secretion of anorexigenic gut hormones. Particularly, EGCG induced secretion of all three hormones. In an ex vivo assay using murine intestines, EGCG also released CCK from the duodenum, and GLP-1 from the ileum. These results suggest that EGCG may affect appetite via gut hormones.

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