An Expedient Strategy towards an Advanced Pyrrolidine Intermediate for the Synthesis of Pyrrolizidine Alkaloids

• Smritilekha Bera

  School of Chemical Sciences, Central University of Gujarat

• Dhananjoy Mondal

  School of Chemical Sciences, Central University of Gujarat

• Bhaskar Chatterjee

  Department of Chemistry, University of Kalyani

抄録

The asymmetric synthesis of a new pyrrolidine intermediate and a preceding amino triol derivative was accomplished using Crimmins’ modified Evans aldol reaction as the key step. The synthetically useful pyrrolidine intermediate is expected to serve as the immediate precursor of biologically important pyrrolizidine alkaloids (−)-isoretronecanol and (−)-cremastrine. In addition, the amino triol subunit acts as a useful intermediate for the synthesis of oxocane heterocycles.

収録刊行物

• Chemistry Letters

  Chemistry Letters 44 (9), 1260-1262, 2015-06-13

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360283694082381952
• NII論文ID: 130005096897
• DOI: 10.1246/cl.150188
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/44/9/1260/55638071/cl.150188.pdf
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