An Hepatitis C Virus (HCV)/HIV Co-Infected Patient who Developed Severe Hepatitis during Chronic HCV Infection: Sustained Viral Response with Simeprevir Plus Peginterferon-Alpha and Ribavirin
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- Hirashima Noboru
- Department of Gastroenterology, National Hospital Organization Nagoya Medical Center, Japan
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- Iwase Hiroaki
- Department of Gastroenterology, National Hospital Organization Nagoya Medical Center, Japan
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- Shimada Masaaki
- Department of Gastroenterology, National Hospital Organization Nagoya Medical Center, Japan
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- Imamura Junji
- Department of Infectious Diseases and Immunology Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan
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- Sugiura Wataru
- Department of Infectious Diseases and Immunology Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan
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- Yokomaku Yoshiyuki
- Department of Infectious Diseases and Immunology Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan
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- Watanabe Tsunamasa
- Department of Infectious Diseases and Immunology Clinical Research Center, National Hospital Organization Nagoya Medical Center, Japan Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Japan
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抄録
We herein describe the case of a 42-year-old man who developed severe hepatitis caused by hepatitis C virus (HCV) infection at 14 years after the start of human immunodeficiency virus (HIV) treatment. Surprisingly, the levels of alanine aminotransferase (ALT) fluctuated, reaching a peak higher than 1,000 IU/L during chronic HCV infection, and the hepatic histology showed advanced liver fibrosis at 3 years after the primary HCV infection. He was treated with simeprevir, peginterferon-alpha, and ribavirin with a sustained viral response. We conclude that HCV/HIV co-infected patients need to commence anti-HCV therapy when the levels of ALT fluctuate severely under successful HIV control.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (17), 2173-2177, 2015
一般社団法人 日本内科学会