CD105 expression in oral capillary hemangiomas and cavernous hemangiomas
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- Matsumoto Naoyuki
- Department of Pathology, Nihon University School of Dentistry
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- Tsuchiya Motomi
- Department of Pathology, Nihon University School of Dentistry
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- Nomoto Shouta
- Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
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- Matsue Yasuyoshi
- Department of Pathology, Nihon University School of Dentistry
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- Nishikawa Yohichi
- Department of Pathology, Nihon University School of Dentistry
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- Takamura Tsuyoshi
- Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
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- Oki Hidero
- Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
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- Komiyama Kazuo
- Department of Pathology, Nihon University School of Dentistry
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Abstract
Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 (endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P < 0.01). These findings suggest that the biological characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. In contrast, the ECs of cavernous hemangiomas lacked proliferative activity. These results suggest that angiogenesis and vasodilatation of pre-existing blood vessels are important in the development of capillary hemangioma and cavernous hemangioma, respectively. (J Oral Sci 57, 45-53, 2015)
Journal
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- Journal of Oral Science
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Journal of Oral Science 57 (1), 45-53, 2015
Nihon University School of Dentistry
