母集団PKPD解析の実際

• 小松 完爾

  アステラス製薬株式会社

書誌事項

タイトル別名

• Practical Aspects of Population Pharmacokinetics & Pharmacodynamics
• ボシュウダン PKPD カイセキ ノ ジッサイ

抄録

The practical aspects of population pharmacokinetics / pharmacodynamics (PK/PD) are summarized. Recently, the progress and application of Model-Based Drug Development (MBDD) in pharmaceutical industries is remarkable and the acceptance of model-based results are getting wider in regulatories of US, EU and Japan. In MBDD, PKPD modeling based on nonlinear mixed effects model (NLMEM) plays an important role, and it provides the quantitative results which help the decision-making in projects. The understanding of its methodology is quite important for pharmacometricians and biostatisticians. In this article, objective, design and modeling methodology (scheme, diagnostics and validation) are briefly described. The research on methodology in NLMEM is still growing, and pharmacometricians should follow its rapid evolution.

収録刊行物

• 計量生物学

  計量生物学 36 (Special_Issue), S49-S63, 2015

  日本計量生物学会

キーワード

• Model-based drug development
• nonlinear mixed effects model
• statistical modeling
• pharmacokinetics

詳細情報

• CRID: 1390001204369765632
• NII論文ID: 130005097964
• NII書誌ID: AA11591618
• DOI: 10.5691/jjb.36.s49
• ISSN: 21856494
• ISSN: 09184430
• NDL書誌ID: 026672153
• Web Site: http://id.ndl.go.jp/bib/026672153
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026672153
• Web Site: https://www.jstage.jst.go.jp/article/jjb/36/Special_Issue/36_S49/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可