Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters

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Author(s)

    • Gi Min Gi Min
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Wanibuchi Hideki
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Fujioka Masaki
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Yamano Shotaro
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Shimomura Eri
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Kanki Masayuki
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Kawachi Satoko
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Tachibana Hirokazu
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Tatsumi Kumiko
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine
    • Fang He
    • Department of Molecular Pathology, Osaka City University Graduate School of Medicine

Abstract

Based on the findings of epidemiological studies in Japan that occupational exposure to 1,2-dichloropropane (1,2-DCP) was associated with increased cholangiocarcinomas, 1,2-DCP has recently been classified as being carcinogenic to humans (Group 1). However, the cholangiocarcinogenicity of 1,2-DCP has not been demonstrated experimentally, and it was negative for cholangiocarcinogenicity in rats and mice. The present study determined the effects of 1,2-DCP on N-nitrosobis(2-oxopropyl)amine (BOP)-induced cholangiocarcinogenesis in male hamsters. We found that 1,2-DCP did not enhance the development of BOP-induced atypical biliary hyperplasia and did not induce any lesions in liver bile duct when administered alone. Notably, 1,2-DCP had no effect on the proliferative activity of bile duct epithelial cells regardless of BOP-initiation. These results demonstrate that 1,2-DCP lacks promoting effects on BOP-induced cholangiocarcinogenesis and suggest the possibility that 1,2-DCP is not cholangiocarcinogenic to the hamster in the present model. In addition, 1,2-DCP also lacks promoting effects on pancreatic, lung, and renal carcinogenesis. As the occurrence of occupational cholangiocarcinomas in Japan might be attributed to exposure to multiple chemicals, the results of the present study indicate that it will be necessary to determine the cholangiocarcinogenic effects of concurrent exposure of 1,2-DCP and the other halogen solvents to which workers with cholangiocarcinomas were exposed.

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 40(5), 647-656, 2015

    The Japanese Society of Toxicology

Codes

  • NII Article ID (NAID)
    130005098383
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • ISSN
    0388-1350
  • NDL Article ID
    026793212
  • NDL Call No.
    Z19-1022
  • Data Source
    NDL  J-STAGE 
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