Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity
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- Ishii Masaki
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Matsumoto Yasuhiko
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Sekimizu Kazuhisa
- Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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抄録
Candida albicans, Candida tropicalis, Candida grabrata, and Cryptococcus neoformans are causative pathogens of opportunistic diseases in immunocompromised human patients. Silkworms are killed by injection of these pathogenic fungi into their hemolymph. In this paper, we describe recent results by our laboratory and other researchers using gene-deficient strains of these pathogenic fungi. The silkworm is considered to be a useful model animal for understanding the pathogenicity of these fungi. Silkworms are also beneficial for evaluating therapeutically active anti-fungal reagents.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 9 (4), 234-237, 2015
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会