Arsenic (+3 Oxidation State) Methyltransferase(AS3MT)遺伝子多型と無機ヒ素のメチル化能力との関連  [in Japanese] Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic  [in Japanese]

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Author(s)

    • 阿草 哲郎 AGUSA Tetsuro
    • 愛媛大学沿岸環境科学研究センター|現所属:熊本県立大学環境共生学部環境資源学科 Center for Marine Environmental Studies (CMES), Ehime University|Present affiliation: Department of Environmental Resources, Graduate School of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
    • VIET Pham Hung Hung VIET Pham
    • Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam
    • 岩田 久人 IWATA Hisato
    • 愛媛大学沿岸環境科学研究センター Center for Marine Environmental Studies (CMES), Ehime University
    • 國頭 恭 KUNITO Takashi
    • 信州大学理学部物質循環学科 Department of Environmental Sciences, Faculty of Science, Shinshu University
    • LAN Vi Thi Mai Thi Mai LAN Vi
    • Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam
    • MINH Tu Binh Binh MINH Tu
    • Faculty of Chemistry, Hanoi University of Science, Vietnam National University, Vietnam Faculty of Chemistry, Hanoi University of Science, Vietnam National University, Vietnam
    • TRANG Pham Thi Kim Thi Kim TRANG Pham
    • Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam Research Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, Vietnam
    • 高橋 真 TAKAHASHI Shin
    • 愛媛大学農学部生物環境保全学 Department of Life Environment Conservation, Faculty of Agriculture, Ehime University

Abstract

Arsenic metabolism affects the susceptibility of humans to arsenic toxicity; therefore, clarification of the factors associated with individual variations in arsenic metabolism is an important task. Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using <i>S</i>-adenosyl-<span style="font-variant: small-caps;">l</span>-methionine (AdoMet), have been reported to modify arsenic methylation. In this review, we summarize studies conducted by us in Vietnam and by others on the association of AS3MT genetic polymorphisms with arsenic metabolism as well as human health effects. Most of the SNPs in AS3MT showed inconsistent results in terms of genotype-dependent differences in arsenic metabolism among the studies. However, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the study population: AS3MT 12390 (rs3740393) affected the second step of methylation of arsenic, whereas 14458 (rs11191439) affected the first methylation step.

Journal

  • Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 70(3), 186-196, 2015

    The Japanese Society for Hygiene

Codes

  • NII Article ID (NAID)
    130005098973
  • NII NACSIS-CAT ID (NCID)
    AN00185923
  • Text Lang
    JPN
  • ISSN
    0021-5082
  • NDL Article ID
    026796335
  • NDL Call No.
    Z19-194
  • Data Source
    NDL  J-STAGE 
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