Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp

• Ayane Watanabe

• Osamu Ohno

• Maho Morita

Abstract

Novel biselyngbyaside analogs, biselyngbyolide C (1) and biselyngbyasides E (2) and F (3), were isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The gross structures of 1–3 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. These compounds inhibited the growth of HeLa and HL60 cells. From the results of an MTT assay, the geometry of the trisubstituted olefin in the side chain and the lack of the sugar moiety were found to be important for the biological activity. In addition, 1 was found to exhibit ER stress- and apoptosis-inducing activities in HeLa cells.

Journal

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 88 (9), 1256-1264, 2015-09

  Tokyo : Chemical Society of Japan

Keywords

• General Chemistry

Details

• CRID: 1523951029914934016
• NII Article ID: 130005099090
• NII Book ID: AA00580132
• ISSN: 00092673
• ISSN: 13480634
• DOI: 10.1246/bcsj.20150117
• NDL BIB ID: 026736045
• Web Site: http://id.ndl.go.jp/bib/026736045
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026736045
• Web Site: https://academic.oup.com/bcsj/article-pdf/88/9/1256/56278323/bcsj.20150117.pdf
• Text Lang: en
• NDL Source Classification:
  • ZP1(科学技術--化学・化学工業)
• Data Source:
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN