Intracerebroventricular injection of adiponectin regulates locomotor activity in rats

• Miyatake Yumiko

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Shiuchi Tetsuya

  Department of Integrative Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School PRESTO, Japan Science and Technology Agency

• Ueta Tomoyo

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Taniguchi Yasuko

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Futami Akari

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Sato Fukiko

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Kitamura Tadahiro

  Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University

• Tsutsumi Rie

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Harada Nagakatsu

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Nakaya Yutaka

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

• Sakaue Hiroshi

  Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School

Abstract

Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays: home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus. J. Med. Invest. 62: 199-203, August, 2015

Journal

• The Journal of Medical Investigation

  The Journal of Medical Investigation 62 (3.4), 199-203, 2015

  The University of Tokushima Faculty of Medicine

Keywords

• Adiponectin
• spontaneous activity
• brain

Details

• CRID: 1390282679220906496
• NII Article ID: 130005099147
• NII Book ID: AA11166929
• DOI: 10.2152/jmi.62.199
• ISSN: 13496867
• ISSN: 13431420
• PubMed: 26399348
• Web Site: http://repo.lib.tokushima-u.ac.jp/111279
• Web Site: https://www.jstage.jst.go.jp/article/jmi/62/3.4/62_199/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016247013
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed