Difference in interleukin-8 transcriptional activity induced in THP-G8 cells by particulate matter collected in winter and summer in western Japan

DOI IR Web Site PubMed 21 References
  • Watanabe Masanari
    Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine
  • Kurai Jun
    Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine
  • Minato Sayaka
    Tottori Prefectural Institute of Health and Environment
  • Noma Hisashi
    Department of Data Science, Institute of Statistical Mathematics
  • Sano Hiroyuki
    Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine
  • Saito Rumiko
    Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
  • Aiba Setsuya
    Department of Dermatology, Tohoku University Graduate School of Medicine
  • Oshimura Mitsuo
    Chromosome Engineering Research Center, Tottori University
  • Hatakeyama Keisuke
    Tottori Prefectural Institute of Health and Environment
  • Yamasaki Akira
    Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine
  • Shimizu Eiji
    Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine

Search this article

Abstract

Background: Airborne particulate matter (PM) may stimulate production of pro-inflammatory cytokines, and thus exposure to PM affects pulmonary diseases. However, the effects of PM on pulmonary diseases have differed among studies. Methods: PM was collected from February 2 to 28 (winter) and June 1 to 17 (summer) in 2013 in Yurihama, Japan, using filters to separate particles with different aerodynamic diameters (1.1 to <2.2 μm, 2.2 to <3.3 μm, 3.3 to <7.0 μm, and 7.0 to <10 μm). Interleukin (IL)-8 transcriptional activity in THP-G8 cells was examined in response to winter and summer PM with different diameters. Results: IL-8 transcriptional activity induced by winter PM was significantly higher than that with summer PM for each diameter. For winter PM, IL-8 activity increased with an increased diameter, whereas this activity did not differ between a solvent control and each summer PM diameter. This indicates that summer PM does not stimulate production of IL-8 in THP-G8 cells. Conclusion: The effects of PM on production of pro-inflammatory cytokines differ with the season and PM diameter. This suggests that the compositions of PM differ on season, and the evaluation of compositions of PM is important in understanding the association of health with short-term exposure to PM. J. Med. Invest. 62: 145-148, August, 2015

Journal

References(21)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top