A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population
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- Choi Youngju
- Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
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- Miura Masahiro
- Department of Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan
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- Nakata Yoshio
- Faculty of Medicine, Division of Sports Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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- Sugasawa Takehito
- Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
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- Nissato Sumiko
- Department of Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan
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- Otsuki Takeshi
- Faculty of Sport and Health Sciences, Ryutsu Keizai University, Ryugasaki 301-8555, Japan
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- Sugawara Jun
- Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan
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- Iemitsu Motoyuki
- Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu 525-8577, Japan
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- Kawakami Yasushi
- Department of Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan
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- Shimano Hitoshi
- Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba 305-8575, Japan
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- Iijima Yoshimi
- Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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- Tanaka Kiyoji
- Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
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- Kuno Shinya
- Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
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- Allu Prasanna K. R.
- Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, India
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- Mahapatra Nitish R.
- Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, India
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- Maeda Seiji
- Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan
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- Takekoshi Kazuhiro
- Faculty of Medicine, Division of Sports Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
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Abstract
Chromogranin A (CHGA) is a major protein in the secretory granules of chromaffin cells. CHGA also gives rise to cardiovascular/metabolism regulatory peptides, such as catestatin (CST) and pancreastatin (PST). While CST is a potent inhibitor of catecholamine secretion, PST is a potent physiological inhibitor of glucose-induced insulin secretion. Recently, several SNPs were identified in the CST and PST domains of CHGA locus in different populations. Among the discovered SNPs, CST variant allele Ser-364 was associated with blood pressure alteration and PST variant allele Ser-297 was associated with significantly higher plasma glucose level. In this study, we examined whether these CST and PST variant alleles exist and influence cardiovascular and metabolic phenotypes in Japanese population. Our study comprised of 343 Japanese subjects aged 45-85 years (143 men and 200 women, mean age 66 ± 8 years). We determined the genotypes of CST and PST by PCR-direct sequencing method and carried out genotype-phenotype association analysis. In 343 participants, the minor allele frequency of CST variant Ser-364 was 6.10%. On the other hand, we did not detect the PST variant Ser-297 in this entire study population. The presence of Ser-364 allele was associated with increased in baPWV (an index of systemic arterial stiffness) that suggests an initiation and/or progression atherogenesis and hypertension. The Ser-364 allele was also associated with elevated systolic blood pressure and pulse pressure, consistent with increased baPWV. In conclusion, the CST Ser-364 allele may increase the risk for cardiovascular diseases in Japanese population.
Journal
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- Endocrine Journal
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Endocrine Journal 62 (9), 797-804, 2015
The Japan Endocrine Society
