Horizontal transmission and phylogenetic analysis of bovine leukemia virus in two districts of Miyazaki, Japan

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Author(s)

    • MEKATA Hirohisa MEKATA Hirohisa
    • Project for Zoonoses Education and Research, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan
    • SEKIGUCHI Satoshi SEKIGUCHI Satoshi
    • Laboratory of Animal Infectious Disease and Prevention, Department of Veterinary Medicine, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan|Center for Animal Disease Control, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan
    • KONNAI Satoru [他] KONNAI Satoru
    • Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060–0818, Japan
    • KIRINO Yumi
    • Project for Zoonoses Education and Research, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan|Laboratory of Veterinary Parasitic Diseases, Interdisciplinary Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan
    • HORII Yoichiro
    • Center for Animal Disease Control, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan|Laboratory of Veterinary Parasitic Diseases, Interdisciplinary Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan
    • NORIMINE Junzo
    • Center for Animal Disease Control, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan

Abstract

Horizontal transmission is recognized as a major infection route for bovine leukemia virus (BLV), and cattle with high viral loads are considered to be a major infectious source in a herd. However, a correlation between viral loads and the risk of infection has been insufficient to use as a foundation for BLV control strategies. In this report, we examined the epidemiology of BLV infection and the infectious source in a local area. In 2013–2014, BLV infection was investigated in 1,823 cattle from 117 farms in two adjacent districts, Miyazaki, Japan. Seropositive samples for BLV were detected with 88 cattle and in 14 farms. Phylogenetic analysis revealed that 94% of the isolates clustered into genotype I and the remaining isolate into genotype III. Among genotype I, genetically distinct strains were spread at each farm, and cattle infected with less than 3 copies/100 cells did not transmit BLV to other cattle for more than thirty months. This is the first report of concrete data of viral load in relation to viral horizontal transmission under the field condition. The data facilitate farmers and veterinarians understanding the status of BLV infected cattle. This research contributes to BLV infection control and the development of effective BLV eradication programs.

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 77(9), 1115-1120, 2015

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130005100718
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    026787755
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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