ヒラメのエドワジエラ症に対するホスホマイシンの治 療効果(英文) [in Japanese] Therapeutic Efficacy of Oral Administration of Fosfomycin on Experimentally Induced Edwardsiellosis in Japanese Flounder [in Japanese]
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Juvenile Japanese flounder <i>Paralichthys olivaceus</i> were immersion-challenged (2.0 × 10<sup>6</sup> CFU/mL, 60 min) with <i>Edwardsiella tarda</i> NUF806 strain. From the following day, diets containing fosfomycin (FOM) calcium were administrated orally at concentrations of 20, 40 or 80 mg potency/kg body weight/day for 6 consecutive days. Cumulative mortality of fish during the observation period of 21 days after the drug administration was significantly lower in all groups of FOM-treated fish than that in the control group. In addition, NUF806 strain and recent clinical isolates (n = 30) of <i>E. tarda</i> examined were all susceptible to FOM, with MIC of 2-4 μg/mL when estimated using the glucose-6-phosphate-containing Mueller-Hinton broth. The results suggest that FOM is a promising candidate for the treatment of edwardsiellosis in cultured Japanese flounder.
- Fish Pathology
Fish Pathology 50(3), 123-126, 2015
The Japanese Society of Fish Pathology