Graphene Oxide-based Amplified Fluorescence Sensor for Nucleic Acid Detection through Target-catalyzed Hairpin Assembly
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The fluorescence signal of a DNA sensor based on strand exchange on graphene oxide was amplified using a DNA circuit that consisted of autonomous cyclic reactions catalyzed by the target. Selectivity for the target was retained after signal amplification. The fluorescence signal was enhanced ca. 50–100-fold at sub-nanomolar target concentrations under isothermal conditions at 35 °C.
- Chemistry Letters
Chemistry Letters 44(10), 1353-1355, 2015
The Chemical Society of Japan