Chemical Modification of Lipase for Rational Enhancement of Enantioselectivity
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- Tadashi Ema
- Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
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- Hiroki Inoue
- Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
抄録
<jats:title>Abstract</jats:title> <jats:p>Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.</jats:p>
収録刊行物
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- Chemistry Letters
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Chemistry Letters 44 (10), 1374-1376, 2015-10
Oxford University Press (OUP)
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詳細情報 詳細情報について
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- CRID
- 1360002219105718528
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- NII論文ID
- 130005101495
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- ISSN
- 13480715
- 03667022
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