ミエロイド系細胞の分化と転写因子  [in Japanese] Transcription factors in the development of myeloid cells  [in Japanese]

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Author(s)

    • 田村 智彦 TAMURA Tomohiko
    • 横浜市立大学大学院医学研究科 免疫学 Department of Immunology, Yokohama City University Graduate School of Medicine
    • 小泉 真一 KOIZUMI Shin-ichi
    • 横浜市立大学大学院医学研究科 免疫学 Department of Immunology, Yokohama City University Graduate School of Medicine
    • 黒滝 大翼 KUROTAKI Daisuke
    • 横浜市立大学大学院医学研究科 免疫学 Department of Immunology, Yokohama City University Graduate School of Medicine

Abstract

造血幹細胞が前駆細胞を経て,同一のゲノム配列を持ちながらも機能の異なる様々な血液細胞に分化するには,転写因子による細胞種特異的な遺伝子発現パターンの確立が重要である。そして遺伝子転座や変異による造血系転写因子の異常は白血病や免疫不全等の疾患を引き起こす。転写研究は,全ゲノムクロマチン免疫沈降シーケンシング(ChIP-seq)やRNA-seq等の網羅的分析技術が集結し,新たな時代に入っている。本総説ではミエロイド系特に単核貪食細胞系(単球・マクロファージや樹状細胞)への分化に焦点をあて,転写因子の働きをクロマチンの観点を含めて概説する。転写因子が協調あるいは拮抗しながらネットワークを構成し,プロモーター遠位のエンハンサー形成や活性化を調節することで遺伝子発現を調節し細胞の個性を決定することがはっきりして来た。

Hematopoietic stem cells give rise to various blood cell types with diverse functions, although these different cell types harbor essentially identical genome sequences. The basis for this cell type diversity is the establishment of specific gene expression patterns through transcription factor regulation. Transcription factors recognize and bind to specific nucleotide sequences in target genes and recruit chromatin modifiers to alter the epigenetic status of these genes, thereby controlling their expression. Dysregulation of these processes can cause diseases such as leukemia. Due to rapid advances in high-throughput experimental techniques including chromatin immunoprecipitation-sequencing (ChIP-seq) and RNA-seq, the study of transcription factors is now entering a new era. In this review, we update the current knowledge of developmental pathways in myeloid cells, particularly mononuclear phagocytes (i.e., monocytes/macrophages and dendritic cells), and the transcription factors known to be required for their development. We subsequently provide an overview of the cooperative and antagonistic mechanisms by which the myeloid transcription factors regulate their target genes, with an emphasis on chromatin biology.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56(10), 1861-1870, 2015

    The Japanese Society of Hematology

Codes

  • NII Article ID (NAID)
    130005103301
  • NII NACSIS-CAT ID (NCID)
    AN00252940
  • Text Lang
    JPN
  • ISSN
    0485-1439
  • NDL Article ID
    026758124
  • NDL Call No.
    Z19-295
  • Data Source
    NDL  J-STAGE 
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