Regulation of immune responses by ATP-hydrolyzing ecto-enzymes

DOI Web Site 参考文献41件
  • Takeda Kiyoshi
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan
  • Tsai Shih Han
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
  • Kayama Hisako
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

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Extracellular adenosine 5'-triphophate (ATP) mediates the immune response. Several ecto-enzymes hydrolyze ATP, including the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and ecto-nucleotide pyrophosphate/phosphodiesterase (E-NPP) protein families. Among these, E-NTPD1, E-NTPD7, and E-NPP3 have been shown to regulate the immune response. E-NTPD1 is expressed in lymphocytes and myeloid cells and modulates their function. E-NTPD7, which is selectively expressed in the epithelial cells of the small intestine, regulates Th17 responses in the small intestine by controlling ATP levels. E-NPP3 is rapidly induced on activated basophils and mast cells, and regulates ATP-dependent activation in basophils and mast cells to prevent chronic allergic inflammation. Thus, ATP-hydrolyzing ecto-enzymes modulate the immune response through ATP hydrolysis.

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