<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study
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<b><i>Aim</i></b><b>: </b>An increasing number of studies have linked <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection to extragastric diseases; however, the role of <i>H. pylori</i> in the pathogenesis of cardiovascular disease (CVD) remains controversial. We examined the association between <i>H. pylori</i> infection and risk of death from coronary heart disease (CHD) and stroke in a nested case-control study within a large prospective cohort study of Japanese subjects.<br><b><i>Methods</i></b><b>:</b> The cases were 627 subjects who died from CHD and stroke during the follow-up period until December 31, 2003, and 627 control subjects were selected and matched to cases on sex, age, and area. Commercial immunoassay IgG enzyme-linked immunosorbent assay kits were used for the determination of the seropositivity for <i>H. pylori</i>. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model.<br><b><i>Results</i></b><b>:</b> Overall, <i>H. pylori</i> infection was not associated with CVD (CHD and stroke) mortality risk. The multivariable OR was 0.96 (0.76–1.21) for the <i>H. pylori</i> positive subjects in comparison with <i>H. </i><i>pylori</i> negative subjects. As for the subtype of CVD, <i>H. pylori</i> appears to be inversely associated with the risk of death from CHD, with an OR of 0.79 (0.50–1.25), but this was not statistically significant. No significant association was observed between <i>H. pylori</i> infection and stroke, with an OR of 1.02 (0.78–1.33).<br><b><i>Conclusion</i></b><b>: </b>The results of this nested case-control study suggest that there is no association between <i>H. pylori</i> infection and CHD and stroke mortality risk in otherwise healthy, elderly Japanese individuals.
- Journal of Atherosclerosis and Thrombosis
Journal of Atherosclerosis and Thrombosis 22(11), 1207-1213, 2015
Japan Atherosclerosis Society