Pulmonary effects in workers exposed to indium metal: A cross‐sectional study
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- Nakano Makiko
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
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- Tanaka Akiyo
- Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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- Hirata Miyuki
- Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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- Iwasawa Satoko
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
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- Omae Kazuyuki
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
書誌事項
- タイトル別名
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- Pulmonary effects in workers exposed to indium metal: A cross-sectional study
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Objectives: Indium was added to the list of substances regulated by the Ordinance on Prevention of Hazards due to Specified Chemical Substances (OPHSCS) in 2013. Indium metal (IM), however, is not regulated by the OPHSCS due to insufficient information on pulmonary effects following exposure. Methods: From 2011 to 2013, a cross-sectional study was conducted on 141 IM-exposed workers at 11 factories. Subjective symptoms were assessed, including levels of serum biomarkers, spirometry readings and total and diffuse lung capacity. Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) were selected as biomarkers of interstitial pneumonia. Indium serum concentration (In-S) and personal air sampling data were used to estimate exposure. Subjects were categorized into 5 groups based on occupation and type of exposure: smelting, soldering, dental technician, bonding and other. Results: The highest level of In-S was 25.4 µg/l, and the mean In-S level was significantly higher in the smelting group than in other groups. In the smelting group, the prevalence of increased In-S levels was 9.1%, while that of abnormal KL-6 was 15.2%. A significant dose-effect relationship was observed between the In-S and KL-6 levels. No marked differences were observed between any of the groups in SP-D values, pulmonary symptoms, or pulmonary function test results. A total of 31% of the subjects worked in an environment with IM levels exceeding 0.3 µg/m3, which requires a protective mask to be worn. Conclusions: For workers exposed to IM, work environments should be monitored, appropriate protective masks should be worn, and medical monitoring should be conducted according to the OPHSCS.(J Occup Health 2015; 57: 346–352)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 57 (4), 346-352, 2015
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204454448896
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- NII論文ID
- 130005106131
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 026633899
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- PubMed
- 25958975
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可