Usefulness of liver fibrosis markers ELF in chronic hepatitis

• Takashima Tomoyuki

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Iijima Hiroko

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine Ultrasound Imaging Center, Hyogo College of Medicine

• Aoki Tomoko

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Nakano Chikage

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine Ultrasound Imaging Center, Hyogo College of Medicine

• Aizawa Nobuhiro

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Kishino Kyohei

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Shimono Yoshihiro

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Hasegawa Kunihiro

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Takata Ryo

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Yo Kazunori

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Ishii Akio

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Sakai Yoshiyuki

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Nishimura Takashi

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine Ultrasound Imaging Center, Hyogo College of Medicine

• Nishikawa Hiroki

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Iwata Yoshinori

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Ikeda Naoto

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Enomoto Hirayuki

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

• Hirota Seiichi

  Division of Surgical Pathology, Hyogo College of Medicine

• Fujimoto Jiro

  Department of Surgery Hepato-biliary-pancreatic Surgery, Hyogo College of Medicine

• Yano Hirohisa

  Department of Pathology, Kurume University School of Medicine

• Nakashima Osamu

  Department of Clinical Laboratory Medicine, Kurume University School of Medicine

• Kage Masayoshi

  Department of Diagnostic Pathology, Kurume University School of Medicine

• Nishiguchi Shuhei

  Division of Hepatobiliary and Pancreatic Diseases Department of Internal Medicine, Hyogo College of Medicine

Bibliographic Information

Other Title

• 慢性肝炎における肝線維化マーカーELFスコアの有用性
• マンセイ カンエン ニ オケル カン センイカ マーカー ELF スコア ノ ユウヨウセイ

Abstract

We evaluated the usefulness of the enhanced liver fibrosis panel (ELF, ADVIA Centaur^®), the new method to assess liver fibrosis using serum fibrosis markers in patients with chronic hepatitis, and compared the result with other serological fibrosis markers. 338 patients with chronic hepatitis were included. ELF score, which consists of hyaluronic acid, procollagen type III propeptide (PIIIP) and tissue inhibitor of matrix metalloproteinase -1 (TIMP-1) was F0; 8.6±1.0, F1; 9.0±0.9, F2; 9.9±1.3, F3; 10.8±1.1, F4; 11.3±0.9, and increased with the development of fibrosis. The area under the receiver operating characteristic curve (AUROC) for the diagnosis of liver cirrhosis was 0.867 and showed good diagnostic accuracy (p<0.001). The ELF score is a useful noninvasive tool for the diagnosis of liver fibrosis stage in patients with chronic hepatitis.

Journal

• Kanzo

  Kanzo 56 (10), 543-545, 2015

  The Japan Society of Hepatology

Keywords

• liver fibrosis
• non-invasive test
• ELF

Details

• CRID: 1390001204793887744
• NII Article ID: 130005106527
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.56.543
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 026815413
• Web Site: http://id.ndl.go.jp/bib/026815413
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026815413
• Web Site: https://www.jstage.jst.go.jp/article/kanzo/56/10/56_543/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016055272
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed