Prevalence of amyloid deposition in mature healthy chickens in the flock that previously had outbreaks of vaccine-associated amyloidosis

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  • IBI Kanata
    Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu-shi, Gifu 501–1193, Japan
  • MURAKAMI Tomoaki
    Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3–5–8 Saiwai-cho, Fuchu-shi, Tokyo 183–8509, Japan
  • GODA Wael Mohamed
    Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu-shi, Gifu 501–1193, Japan
  • KOBAYASHI Naoki
    Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu-shi, Gifu 501–1193, Japan
  • ISHIGURO Naotaka
    Laboratory of Food and Environmental Hygiene, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu-shi, Gifu 501–1193, Japan
  • YANAI Tokuma
    Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu-shi, Gifu 501–1193, Japan

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  • Pathology : Prevalence of amyloid deposition in mature healthy chickens in the flock that previously had outbreaks of vaccine-associated amyloidosis

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Abstract

Avian amyloid A (AA) amyloidosis is commonly observed in adult birds with chronic inflammation, such as that caused by bacterial infection. We previously described vaccine-associated AA amyloidosis in juvenile chickens. In this study, the prevalence of amyloid deposition was measured in mature healthy chickens that survived a previous outbreak of avian AA amyloidosis while they were juveniles. Herein, we analyzed the amyloid deposition in mature chickens and compared the prevalence of amyloid deposition with juvenile chickens obtained in our previous study (Murakami et al., 2013). We found that: 1) amyloid deposition in the liver was absent in mature chickens, while juvenile chickens had a rate of 24%; 2) amyloid deposition in the spleen was observed in 36% of juvenile chickens and in 40% of mature chickens; 3) amyloid deposition in the pectoral muscle of mature chickens (43.75%) was approximately half that of juvenile chickens (88%). These results suggest that additional amyloid deposition in chickens previously exposed to AA amyloidosis may not worsen with age. Further, amyloid deposition in chickens may tend to regress when causative factors, such as vaccinations and/or chronic inflammation, are absent.

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