Characterization and tissue distribution of conjugated metabolites of pyrene in the rat

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  • SAENGTIENCHAI Aksorn
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngam Wong Wan Rd, Lat Yao Chatuchak, Bangkok 10900, Thailand
  • IKENAKA Yoshinori
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa
  • DARWISH Wageh Sobhy
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt
  • NAKAYAMA Shouta M.M.
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan
  • MIZUKAWA Hazuki
    Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan
  • ISHIZUKA Mayumi
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo 060–0818, Japan

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  • Toxicology : Characterization and tissue distribution of conjugated metabolites of pyrene in the rat

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Abstract

Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose public health risks, it is necessary to study their characteristics and tissue-specific distribution. The present study was performed to experimentally characterize PY metabolites and analyze the tissue-specific distribution of the conjugated metabolites after oral administration of PY to rats. PY metabolites, such as pyrenediol-disulfate (PYdiol-diS), pyrenediol-sulfate (PYdiol-S), pyrene-1-sufate (PYOS), pyrene-1-glucuronide (PYOG) and 1-hydroxypyrene (PYOH), were detected in rat urine. Although glucuronide conjugate was the predominant metabolite, the metabolite composition varied among tissues. Interestingly, the proportion of PYOH was high in the large intestine. Furthermore, PYOH was the only PY metabolite detected in feces.

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