The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer

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Author(s)

    • Higashi Akifumi
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Kurisu Satoshi
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Yamamoto Hideya
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Yasui Wataru
    • Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Kihara Yasuki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Dohi Yoshihiro
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Uraoka Naohiro
    • Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Sentani Kazuhiro
    • Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Uga Sayuri
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Kinoshita Hiroki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Sada Yoshiharu
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Kitagawa Toshiro
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan
    • Hidaka Takayuki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan

Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal cancer-related complication. We herein present a case of PTTM that diagnosed antemortem by lung scintigraphy and pulmonary microvascular cytology. The patient was treated with steroid pulse therapy. Although her symptoms temporarily improved, she died of respiratory failure. An autopsy showed PTTM, and an immunohistochemical analysis revealed the expression of osteopontin and CD44 in macrophages that had migrated into the PTTM lesions. These findings suggest that inflammation associated with the interaction between osteopontin and CD44 may play an important role in PTTM.<br>

Journal

  • Internal Medicine

    Internal Medicine 54(22), 2877-2880, 2015

    The Japanese Society of Internal Medicine

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