患肢への経皮的ニトログリセリン投与による間歇性跛行に対する効果の検討  [in Japanese] Transdermal Glyceryl Trinitrate Administration to the Limb of Peripheral Artery Disease Improves Intermittent Claudication  [in Japanese]

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Author(s)

    • 土田 憲 Tsuchida Ken
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 後藤 均 Goto Hitoshi
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 橋本 宗敬 Hashimoto Munetaka
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 赤松 大二朗 Akamatsu Daijirou
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 清水 拓也 Shimizu Takuya
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 河村 圭一郎 Kawamura Keiichirou
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 田島 悠太 Tajima Yuta
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 梅津 道久 Umetsu Michihisa
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan
    • 大内 憲明 Ohuchi Noriaki
    • 東北大学病院移植再建内視鏡外科 Division of Transplantation, Reconstruction and Endoscopic Surgery, Tohoku University Hospital, Miyagi, Japan

Abstract

要旨:11 人のPAD 患者に対し患肢へニトログリセリンテープまたはプラセボテープを貼付し間歇性跛行の改善を評価するクロスオーバー試験を行った。その結果,ニトログリセリンテープ貼付により最大歩行距離の延長がみられ,疼痛出現距離も延長する傾向がみられた。歩行障害質問票(WIQ2)においても改善がみられた。ニトログリセリンテープの患肢への経皮投与は間歇性跛行の新しい治療法になりうると考えられた。

Single-blind crossover study evaluating the efficacy of transdermal administration of glyceryl trinitrate (GTN) for intermittent claudication was performed. Eleven patients who had symptomatic peripheral artery disease (PAD) were enrolled. The patients were administered GTN tape or placebo tape on the calves of the diseased side limb. Treadmill test and answering walking impairment questionnaire (WIQ2) were required before and after 14 days of GTN administration. After 7 days of washout period, they were administered the other tape and had test as well as former period. The patients were randomly divided into GTN tape first group and placebo tape first group. All patients accomplished the whole series and did not show any side effects. The data showed no carry-over effects. Maximum walking distance (MWD) and WIQ2 score significantly increased by the administration of GTN tape. Pain-free walking distance (PWD) had a tendency to increase though that was not statistically significant. Proximal (iliac) lesion group was thought to respond to GTN tape more than distal (infrainguinal) lesion group. The transdermal administration of GTN tape was thought to improve the intermittent claudication of PAD patients.

Journal

  • The Journal of Japanese College of Angiology

    The Journal of Japanese College of Angiology 55(10), 179-184, 2015

    Japanese College of Angiology

Codes

  • NII Article ID (NAID)
    130005108855
  • Text Lang
    JPN
  • ISSN
    0387-1126
  • Data Source
    J-STAGE 
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