Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma

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  • KAMBAYASHI Satoshi
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • IGASE Masaya
    Laboratory of Molecular Diagnosis and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • KOBAYASHI Kosuke
    Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • KIMURA Ayana
    Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • SHIMOKAWA MIYAMA Takako
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • BABA Kenji
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • NOGUCHI Shunsuke
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Laboratory of Molecular Diagnosis and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • MIZUNO Takuya
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Laboratory of Molecular Diagnosis and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Biomedical Science Center for Translational Research, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
  • OKUDA Masaru
    Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan Biomedical Science Center for Translational Research, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

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抄録

Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.

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