Experimental study of influence of direct bisphosphonate administration on bone substitute
-
- YASUDA Atsushi
- Department of Orthodontics, School of Dentistry, Aichi-Gakuin University
-
- MIYAZAWA Ken
- Department of Orthodontics, School of Dentistry, Aichi-Gakuin University
-
- SATO Takuma
- Department of Orthodontics, School of Dentistry, Aichi-Gakuin University
-
- YAGIHASHI Keisuke
- Department of Orthodontics, School of Dentistry, Aichi-Gakuin University
-
- GOTO Shigemi
- Department of Orthodontics, School of Dentistry, Aichi-Gakuin University
Search this article
Abstract
Articular cartilage has a low self-repair ability and natural healing cannot be expected. Treatment using various bone substitutes has been performed, but these have various disadvantages. Compared to autologous bone substitutes, the osteochondral repair ability of allogeneic bone substitutes is low, but the effective and safe utilization of these as a bone substitute may be possible by improving their osteochondral repair ability. We prepared a full-thickness osteochondral defect in the patellar fossa of rabbits, added a bisphosphonate preparation to bovine tooth-derived Demineralized Dentin Matrix (DDM), which has its own osteochondral repair ability, and investigated osteochondral repair ability in the defects. As a result, we suggest that the addition of high-dose BPs inhibits the osteochondral repair ability of DDM.
Journal
-
- Dental Materials Journal
-
Dental Materials Journal 34 (6), 789-795, 2015
The Japanese Society for Dental Materials and Devices
