OUTCOME OF CLIVAL CHORDOMAS AFTER SKULL BASE SURGERIES WITH MEAN FOLLOW-UP OF 10 YEARS

• TAMURA TAKAMITSU

  Department of Neurosurgery, Fukushima Medical University Department of Neurosurgery Graduate School of Medicine, University of the Ryukyus

• SATO TAKU

  Department of Neurosurgery, Fukushima Medical University

• KISHIDA YUGO

  Department of Neurosurgery, Fukushima Medical University

• ICHIKAWA MASAHIRO

  Department of Neurosurgery, Fukushima Medical University

• ODA KEIKO

  Department of Neurosurgery, Fukushima Medical University

• ITO EIJI

  Department of Neurosurgery, Gifu Prefectural Tajimi Hospital

• WATANABE TADASHI

  Department of Neurosurgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan

• SAKUMA JUN

  Department of Neurosurgery, Fukushima Medical University

• SAITO KIYOSHI

  Department of Neurosurgery, Fukushima Medical University

抄録

Background and Objective: Skull base chordomas are clinically malignant because of the difficulty of total removal, high recurrence rate, and occasional drop metastasis. Although aggressive surgical resection and postoperative radiation have been recommended, the long-term outcome remains unsatisfactory.Methods: From 1992 to 2011, we treated 24 patients with skull base chordoma using aggressive surgical removal as a principal strategy. Skull base approaches were selected according to tumor extension to remove the tumor and surrounding bone as completely as possible. After surgery, all patients were closely observed with MRI to find small and localized recurrent tumors, which were treated with gamma-knife radiosurgery or surgical resection. The mean postoperative follow-up duration was 10.2 years (range, 1-17.2 years).Results: The 5-, 10-, and 15-year overall survival rates were 86%, 72%, and 72%, respectively. The 5- and 10-year progression-free survival rates were 47% and 35%, respectively. Tumor extension to the brainstem and partial tumor removal were the factors related to poor survival.Conclusions: Our results suggest that aggressive surgical removal improves the long-term outcome of patients with skull base chordoma. We would like to emphasize that skull base chordomas should be aggressively removed using various skull base approaches.

収録刊行物

• 福島医学会

  福島医学会 61 (2), 131-140, 2015

  福島医学会

キーワード

• clival chordoma
• skull base surgery
• long-term outcome

詳細情報

• CRID: 1390001206305035776
• NII論文ID: 130005113555
• NII書誌ID: AA0065246X
• DOI: 10.5387/fms.2015-12
• ISSN: 21854610
• ISSN: 00162590
• PubMed: 26370681
• Web Site: http://ir.fmu.ac.jp/dspace/handle/123456789/491
• Web Site: https://www.jstage.jst.go.jp/article/fms/61/2/61_2015-12/_pdf
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • PubMed
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