骨等価溶液を用いた骨SPECT評価用ボディファントムの開発

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タイトル別名
  • Development of a Novel Body Phantom with Bone Equivalent Density for Evaluation of Bone SPECT
  • ホネ トウカ ヨウエキ オ モチイタ ホネ SPECT ヒョウカヨウ ボディファントム ノ カイハツ

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We developed a custom-designed phantom for bone single photon emission computed tomography (SPECT)-specific radioactivity distribution and linear attenuation coefficient. The aim of this study was to evaluate the accuracy of the phantom. The lumbar phantom consisted of the trunk of a body phantom (background) containing a cylinder (vertebral body), a sphere (tumor), and a T-shaped container (processus). The vertebral body, tumor, and processus phantoms contained a K2HPO4 solution of bone equivalent density and 50, 300 and 50 kBq/mL of 99mTc, respectively. The body phantom contained 8 kBq/mL of 99mTc solution. SPECT images were acquired using low-energy high-resolution collimation, a 128×128 matrix and 120 projections over 360° with a dwell time of 15 sec/view×4 times. Thereafter, CT images were acquired at 130 kV and 70 ref mAs using adaptive dose modulation. The SPECT data were reconstructed with ordered subset expectation maximization with three-dimensional, scatter, and CT-based attenuation correction. Count ratio, linear attenuation coefficient (LAC), and full-width at half-maximum (FWHM) were measured. Count ratios between the background, the vertebral body, and the tumor in SPECT images were 463.8: 2888.0: 15150.3 (1: 6.23: 32.7). The LAC of the background and vertebral body in the CT-derived attenuation map were 0.155 cm-1 and 0.284 cm-1, respectively, and the FWHM measured from the processus was 15.27 mm. The precise counts and LAC indicated that the phantom was accurate and could serve as a tool for evaluating acquisition, reconstruction parameters, and quantitation in bone SPECT images.

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