粉末冶金学的手法による骨アパタイト結晶粒子の配向化挙動の解明とそれに基づく新規骨代替インプラントの開発

• 中野 貴由

  大阪大学大学院工学研究科マテリアル生産科学専攻

• 石本 卓也

  大阪大学大学院工学研究科マテリアル生産科学専攻

書誌事項

タイトル別名

• Formation of Crystallographic Orientation of Bone Apatite Crystallites Investigated by Powder-Metallurgical Method and Development of Novel Bone Implant Focusing on Apatite Orientation
• 受賞記念講演 平成25年度研究進歩賞 粉末冶金学的手法による骨アパタイト結晶粒子の配向化挙動の解明とそれに基づく新規骨代替インプラントの開発
• ジュショウ キネン コウエン ヘイセイ 25ネンド ケンキュウ シンポショウ フンマツ ヤキンガクテキ シュホウ ニ ヨル ホネ アパタイト ケッショウ リュウシ ノ ハイコウカ キョドウ ノ カイメイ ト ソレニ モトズク シンキコツ ダイタイ インプラント ノ カイハツ

抄録

The preferential orientation and its degree of crystallographic c-axis of biological apatite powder particles dominates bone mechanical function. Based on the importance of the apatite orientation, we are trying to elucidate the mechanisms through which the anisotropic apatite micro-arrangement forms using the regenerated bones and pathological bones including gene-modified ones. Of the many factors that possibly affect apatite orientation, in vivo stress field was found to play a significant role, therefore, applying a sound stress field onto bones is essential to induce a healthy bones that have optimally anisotropic apatite arrangement. From this perspective, bone implants should be developed targeting on the formation and maintenance of healthy apatite orientation and aggressive stress control. Anisotropic porous structure might be a promising strategy to create such implants with the novel concepts. Layer-by-layer additive manufacturing technology that fabricates products with arbitrary shape and inner structure from powdered metal materials is a powerful tool to achieve anisotropically-structured implants for inducing apatite orientation. Our research and development, clarifying bones’ functionalization mechanisms and creating highly-functionalized implants, both of which are closely connected with each other, are ongoing by utilizing powder metallurgy and biology.

収録刊行物

• 粉体および粉末冶金

  粉体および粉末冶金 62 (12), 580-586, 2015

  一般社団法人 粉体粉末冶金協会

キーワード

• apatite orientation
• bone regeneration
• bone implant
• additive manufacturing
• functionalization

詳細情報

• CRID: 1390282681289113600
• NII論文ID: 130005115220
• NII書誌ID: AN00222724
• DOI: 10.2497/jjspm.62.580
• ISSN: 18809014
• ISSN: 05328799
• NDL書誌ID: 027025661
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027025661
• Web Site: https://www.jstage.jst.go.jp/article/jjspm/62/12/62_580/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可