Arterial blood gas anomaly in canine hepatobiliary disease
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- KANEKO Yasuyuki
- Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- TORISU Shidow
- Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- KOBAYASHI Takumi
- Oji Pet Clinic, 1–22–9 Toshima, Kita-ku, Tokyo 114–0003, Japan
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- MIZUTANI Shinya
- Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- TSUZUKI Nao
- Laboratory of Veterinary Surgery, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- SONODA Hiroko
- Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- IKEDA Masahiro
- Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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- NAGANOBU Kiyokazu
- Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen Kibanadai-nishi, Miyazaki-shi, Miyazaki 889–2192, Japan
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Abstract
Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. In addition, respiratory disorders account for 20% of perioperative fatalities in dogs. Therefore, in this study, we evaluated the respiratory status in dogs with hepatobiliary disease by arterial blood gas analysis. PaO2 and PaCO2 were measured. Alveolar-arterial oxygen difference (AaDO2), the indicator of gas exchange efficiency, was calculated. Compared to healthy dogs (control group), hepatobiliary disease dogs had significantly lower PaO2 and higher AaDO2. Hypoxemia (PaO2 of ≤80 mmHg) was observed in 28/71 dogs with hepatobiliary disease. AaDO2 was higher (≥30 mmHg) than the control group range (11.6 to 26.4 mmHg) in 32/71 hepatobiliary disease dogs. By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO2 and higher AaDO2 than in a control group. Dogs with chronic hepatitis also had significantly lower PaCO2. The present study shows that dogs with hepatobiliary disease have respiratory abnormalities more than healthy dogs. Preanesthetic or routine arterial blood gas analysis is likely beneficial to detect the respiratory abnormalities in dogs with hepatobiliary disease, especially extrahepatic biliary obstruction and chronic hepatitis.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 77 (12), 1633-1638, 2015
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206428843136
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- NII Article ID
- 130005115329
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 027052155
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- PubMed
- 26256228
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed